Olgerta Asko

• Asko, Olgerta; Blenkmann, Alejandro Omar; Leske, Sabine Liliana; Foldal, Maja Dyhre; Anais, Llorens & Funderud, Ingrid [Vis alle 10 forfattere av denne artikkelen] (2024). Altered hierarchical auditory predictive processing after lesions to the orbitofrontal cortex. eLIFE. ISSN 2050-084X. 13. doi: 10.7554/eLife.86386.

Se alle arbeider i NVA

• Asko, Olgerta; Volehaugen, Vegard Akselsson; Leske, Sabine Liliana; Funderud, Ingrid; Llorens, Ana?s & Ivanovic, Jugoslav [Vis alle 12 forfattere av denne artikkelen] (2024). Predictive encoding of deviant tone sequences in the human prefrontal cortex.
• Asko, Olgerta; Volehaugen, Vegard Akselsson; Leske, Sabine Liliana; Funderud, Ingrid; Anais, Llorens & Ivanovic, Jugoslav [Vis alle 12 forfattere av denne artikkelen] (2024). Predictive encoding of deviant tone sequences in the human prefrontal cortex. Vis sammendrag

  The ability to use predictive information to guide perception and action relies heavily on the prefrontal cortex (PFC), yet the involvement of its subregions in predictive processes remains unclear. Recent perspectives propose that the orbitofrontal cortex (OFC) generates predictions about perceptual events, actions, and their outcomes while the lateral prefrontal cortex (LPFC) is involved in prospective functions, which support predictive processes, such as selective attention, working memory, response preparation or inhibition. To further delineate the roles of these PFC areas in predictive processing, we investigated whether lesions would impair the ability to build predictions of future events and detect deviations from expected regularities. We used an auditory deviance detection task, in which the structural regularities of played tones were controlled at two hierarchical levels by rules defined at a local (i.e., between tones within sequences) and global (i.e., between sequences) level. We have recently shown that OFC lesions affect detecting prediction violations at two hierarchical levels of rule abstraction, i.e., altered MMN and P3a to local and simultaneous local + global prediction violations (https://doi.org/10.7554/eLife.86386). Now, we focus on the task's predictive aspect and present the latest results showing the involvement of PFC subregions in anticipation of deviances informed by implicit predictive information. Behavioral data shows that deviance expectancy induced faster deviance detection in healthy adults (n=22), suggesting that participants track a state space representation of the task and anticipate upcoming deviant sequences. The analysis of EEG data from patients with focal lesions to the OFC (n = 12) or LPFC (n = 10), and SEEG from the same areas in patients with epilepsy (n = 7), revealed interesting differences. Healthy adults (n = 15) showed modulations of the Contingent Negative Variation (CNV) ¨C a marker of anticipatory activity - tracking the expectancy of deviant tone sequences. However, patients with OFC lesions lacked CNV sensitivity to the predictive context, while patients with LPFC lesions showed moderate sensitivity compared to healthy adults. These results were further supported by intracranial recordings, which revealed expectancy modulation of the high-frequency broadband signal from electrodes in OFC and LPFC, with an earlier latency of activity modulation for the OFC and a later one for the LPFC. Altogether, the complementary approach from behavioral, intracerebral EEG, scalp EEG, and causal lesion data provides compelling evidence for the distinct engagement of the two prefrontal areas in predicting future events and signaling deviations.